Laurens Manning Selected Research

Penicillins (Penicillin)

3/2024	Could late-latent syphilis be treated with a single subcutaneous infusion of long-acting penicillin?
12/2023	Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis: a phase 1 open-label population pharmacokinetic study.
1/2023	Searching for Strep A in the clinical environment during a human challenge trial: a sub-study protocol.
1/2023	Qualitative assessment of healthy volunteer experience receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of late phase clinical studies.
12/2022	Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial).
1/2021	High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.
10/2020	Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: a randomized, crossover, population pharmacokinetic study in healthy adult volunteers.
1/2017	Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever.

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Laurens Manning Research Topics

Disease

35	Infections 04/2024 - 04/2010
16	Malaria 10/2023 - 06/2007
11	Rheumatic Heart Disease (Rheumatic Heart Diseases) 01/2024 - 01/2019
6	Rheumatic Fever (Acute Articular Rheumatism) 01/2024 - 01/2017
5	Pain (Aches) 03/2024 - 10/2020
5	Vivax Malaria 09/2023 - 01/2012
5	COVID-19 04/2023 - 07/2021
4	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2017 - 11/2011
3	Critical Illness (Critically Ill) 02/2023 - 01/2020
3	Wounds and Injuries (Trauma) 08/2022 - 04/2018
3	Bacterial Meningitis 10/2018 - 09/2011
3	Anemia 10/2018 - 04/2010
2	Syphilis 03/2024 - 12/2020
2	Foot Ulcer 08/2022 - 01/2019
2	Foot Diseases 07/2021 - 04/2021
2	Coma (Comas) 01/2019 - 02/2011
2	Bacterial Infections (Bacterial Infection) 10/2018 - 03/2012
2	Parasitemia 12/2014 - 02/2011
1	Latent Syphilis 03/2024
1	Injection Site Reaction 12/2023
1	Convalescence 10/2023
1	Herpes Labialis (Fever Blister) 10/2023
1	Cicatrix (Scar) 04/2023
1	Pharyngitis (Sore Throat) 12/2022
1	Mucormycosis 10/2022
1	Ulcer 08/2022
1	Overweight 06/2022
1	Type 2 Diabetes Mellitus (MODY) 06/2022
1	Staphylococcal Infections 03/2022
1	Abscess 01/2022
1	Lymphadenopathy 01/2022
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Human Influenza (Influenza) 01/2022
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022
1	Sickle Cell Trait 01/2022
1	Diabetes Mellitus 04/2021
1	Cross Infection (Nosocomial Infection) 03/2021
1	Hemorrhage 07/2020
1	Frailty 01/2020

Drug/Important Bio-Agent (IBA)

13	Penicillin G Benzathine (Benzathine Benzylpenicillin)FDA Link 03/2024 - 01/2017
9	Anti-Bacterial Agents (Antibiotics)IBA 04/2024 - 03/2012
8	Penicillins (Penicillin)FDA Link 03/2024 - 01/2017
5	Penicillin G (Benzylpenicillin)FDA LinkGeneric 12/2022 - 01/2017
5	Antimalarials (Antimalarial Agents)IBA 04/2022 - 04/2010
5	artemisinin (artemisinine)IBA 01/2022 - 06/2007
3	Immunoglobulin G (IgG)IBA 10/2023 - 01/2011
3	AntibodiesIBA 10/2023 - 01/2019
3	Proteins (Proteins, Gene)FDA Link 12/2014 - 04/2010
3	AntigensIBA 06/2013 - 01/2012
3	Hemoglobins (Hemoglobin)IBA 01/2012 - 04/2010
2	Plasmodium falciparum erythrocyte membrane protein 1IBA 10/2023 - 01/2019
2	Surface Antigens (Surface Antigen)IBA 10/2023 - 01/2019
2	BCG Vaccine FDA Link 10/2023 - 04/2023
2	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 09/2023 - 01/2017
2	Primaquine FDA Link 09/2023 - 05/2023
2	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2022 - 12/2014
2	artenimol (dihydroartemisinin)IBA 01/2022 - 11/2011
2	Ertapenem (Invanz)FDA Link 10/2021 - 04/2019
2	diformyl dapsone (DFD)IBA 07/2021 - 04/2021
2	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2020 - 10/2018
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 02/2011
2	naphthoquineIBA 05/2016 - 12/2014
2	Chloroquine (Aralen)FDA LinkGeneric 01/2012 - 04/2010
2	Artemether FDA Link 11/2011 - 06/2007
1	boldenone undecylenate (Equipoise)IBA 03/2024
1	ABO Blood-Group SystemIBA 10/2023
1	N 30IBA 10/2023
1	Blood Group Antigens (Blood Groups)IBA 10/2023
1	mesoglycanIBA 02/2023
1	liposomal amphotericin B FDA Link 10/2022
1	Testosterone (Sustanon)FDA Link 06/2022
1	Rifampin (Rifampicin)FDA LinkGeneric 03/2022
1	Interferon-gamma (Interferon, gamma)IBA 01/2022
1	piperaquineIBA 01/2022
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2022
1	VaccinesIBA 01/2022
1	Clindamycin (Cleocin)FDA LinkGeneric 10/2021
1	AnticoagulantsIBA 07/2020
1	Cystatin CIBA 01/2020
1	Floxacillin (Flucloxacillin)IBA 06/2019
1	LactamsIBA 06/2019
1	LincosamidesIBA 06/2019

Therapy/Procedure

11	Therapeutics 04/2022 - 04/2014
8	Injections 01/2024 - 10/2020
5	Prostheses and Implants (Prosthesis) 04/2024 - 01/2016
4	Replacement Arthroplasty 07/2022 - 01/2020
3	Arthroplasty 04/2024 - 01/2020
3	Intramuscular Injections 03/2024 - 07/2020
3	Braces 04/2023 - 10/2021
3	Debridement 01/2023 - 03/2022
2	Subcutaneous Infusions 03/2024 - 12/2023
2	Surgical Amputation (Amputations) 08/2022 - 03/2022
2	Mass Drug Administration 01/2022 - 12/2018
1	Ambulatory Care (Outpatient Care) 03/2024
1	Subcutaneous Injections 01/2024
1	Treatment Delay 05/2023
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2023
1	Skin Transplantation (Skin Grafting) 03/2022
1	Transplantation 01/2022
1	Secondary Prevention 10/2020